Our team

Weatherden is a team of leaders who combine an agile biotech mindset with the proven expertise of pharmaceutical drug discovery and development.”
– Houman Ashrafian, Co-Founder

Leadership

Image
Houman Ashrafian
MA BM Bch DPhil FRCP
Co-Founder
Biography

Houman is a renowned clinician scientist and highly successful entrepreneur. As co-founder of Weatherden, he provides strategic direction to the company’s management team as it continues to evolve into one of the biotech sector’s preferred clinical consulting partners.

He is a Managing Partner at SV Health Investors and was previously Vice President and Head of Clinical Sciences at UCB. With specific interests in immune-oncology, metabolism and genetics, he co-founded Heart Metabolics which successfully repositioned perhexiline as a treatment for hypertrophic cardiomyopathy and heart failure, and the services company Cardiac Report. He has founded six companies since joining SV; Sitryx, Enara Bio, Zarodex, TrexBio, Alchemab and Cellinta.

Houman completed his medical training at the Radcliffe Department of Medicine, University of Oxford where he was appointed as an Honorary Consultant Cardiologist and remains a Visiting Professor and Head of Experimental Therapeutics. During his career, Houman has authored over 70 publications and received dozens of awards for his work.

Image
Duncan McHale
MBBS PhD MRCP
Co-Founder
Biography

Duncan is a clinician scientist and early drug development specialist with over 20 years’ industry experience. He co-founded Weatherden and helps lead the strategic direction of the company, whilst also actively supporting clients with his clinical development expertise. .

He is Chief Medical Officer at Evelo Biosciences, a company developing oral biologics targeting the small intestine and a Venture Partner at SV Health Investors. With previous roles as Vice President and Head of Global Exploratory Development at UCB, Vice President for Personalised Healthcare and Biomarkers at AstraZeneca, and European Head of Translational and Molecular Medicine at Pfizer, he has over 20 years’ experience working across pharmacogenetics, early development and personalised medicine across multiple therapeutic areas.

Duncan completed his PhD in genetics at the University of Leeds and was Visiting Professor in Clinical and Molecular Pharmacology at the University of Liverpool. Previously Chairman of the EFPIA pharmacogenomics working group, Duncan has sat on multiple Medical Research Council panels and was the Innovative Medicine Initiative’s lead on Molecular Taxonomy of Human Disease.

Image
Emma Tinsley
MSci ACA
Chief Executive
Biography

Emma is CEO at Weatherden and a serial entrepreneur. She has built multiple companies with breakthrough therapies and is bringing to market deep tech solutions that will transform clinical trial design efficiency and property ventures that will pioneer a new hybrid network of biotech innovation clusters across Britain and Europe.

Prior to Weatherden, Emma worked in the life sciences division at KPMG before moving into technical advisory, followed by three years at SV Health Investors working on biotech company creation in immunology and oncology. She participates in industry committees and advises early-stage life sciences and EIS funds, is passionate about encouraging broader participation in STEM and in encouraging young entrepreneurs.

Drug development

Image
Sneha Bajpai
BSc
Project Leader
Biography

Sneha is a health tech professional with more than 12 years’ experience in scaling tech-enabled approaches in healthcare across a range of platforms including AI, corporate strategy, and commercialisation in drug development. She brings significant experience of forging public-private partnerships between academia and industry as well as a track record in devising blueprints for Series A raises, due diligence and understanding the competitive landscape.

Image
Ali Bracchi
BSc MSc RGN
Director Clinical Operations
Biography

Ali is a director with more than 20 years experience in clinical operations and a track record of effective study execution, demonstrable by minimal protocol amendments, CAPAs, and extensions to timelines or change orders for out-of-scope expenses. She has extensive knowledge of drug development from FIH to Phase III in a variety of therapeutic areas including cardiovascular, CNS, respiratory and oncology. Ali is an experienced line and matrix manager with experience of leading multifunctional and multinational development teamsShe has experience of managing several parallel clinical programs and has contributed to IMPDs, IBs, DSURs, and CSRs.

Image
Geoff Brooks
BSc
Head Clinical Operations
Biography

Geoff is a clinical research and drug development professional with experience spanning more than 20 years across the pharmaceutical and biotechnology sectors. He brings a distinguished track record of managing early and multiphase clinical operations teams as well as particular expertise in project planning, strategy and implementation – including protocol and IB development – clinical and translational strategies, vendor, operational and clinical site selection and management, managing compounds from pre-clinical development through to clinical proof of concept, and oversight of pre-clinical compounds through IND/CTA enabling studies. He has worked at a senior level on trials Phases I to IV on a variety of international projects involving therapeutic agents ranging from small molecules to gene therapy, and is highly regarded for his success in leading R&D teams.

Image
Raj Dattani
BSc BM BCH
Drug Development Clinician
Biography

Raj studied medicine at the University of Oxford and worked at Guy’s and St Thomas’ hospital before joining Juvenescence as Director of Business Development. In that role, Raj co-led on multiple aspects of company creation, including creation of early research and development plans, and the analysis and competitive mapping of therapeutic areas for indication selection. He also performed extensive commercial and technical due diligence and analysis on a range of assets focussed on ageing and age-related disease, incorporating a review of the key scientific data, KOL opinions, unmet need analyses and competitor therapy area pipeline analyses.

Image
Hakim-Moulay Dehbi
MSc MRes PhD
Drug Development Statistician
Biography

Hakim-Moulay is a medical statistician specialising in the design and analysis of clinical trials, providing critical input to creation, design and delivery of pioneering drug development programmes for clients. His experience extends to all clinical trial phases, from early-phase dose finding studies through to large, randomised Phase III studies across multiple therapeutic and disease areas, including oncology and cardiovascular disease.

Image
Aaron Deveney
BA PhD MBPS
VP Clinical Development
Biography

Aaron is a senior drug development specialist with more than 20 years in clinical drug development, having successfully brought to market a number of compounds. He has extensive experience in the management of development programs, strategic alliances, coordinating of global business initiatives and portfolio management, from first into man to market entry and life cycle management. Aaron has led global and regional clinical development teams in a variety of therapeutic areas in both adult and paediatric indications as well as major transformational programs restructuring global functions.

Image
Matthew Frise
BM BCh MA DPhil FRCP FFICM
Senior Drug Development Clinician
Biography

Matthew is a clinician scientist and medical officer with more than 15 years’ experience in drug development and medical affairs across academic and biotech settings. A specialist in acute medicine and intensive care practice, he brings a strong track record of translational experience across multiple therapeutic areas and is a principal investigator on several multi-centre trials focused on cardiovascular, metabolism, and pulmonary diseases as well as on Covid-19.

Image
Alison Gadd
BSc PhD
Regulatory Expert
Biography

Alison is a senior regulatory affairs professional with more than 25 years’ experience in small and large pharmaceutical companies. She brings worldwide regulatory experience and a strong record in European regulatory procedures, as well as a track record of developing and implementing global regulatory strategies across a wide variety of therapeutic areas. As a former Principal Research Biochemist and Regulatory Scientist, Alison can interact across R&D and commercial functions.

Image
Holly Garratt
BSc
Manager Clinical Operations
Biography

Holly is a clinical study manager with over 20 year’s full life cycle clinical trials management experience in medium and large pharmaceutical companies. She brings extensive knowledge of the clinical trials process and execution of clinical studies from feasibility through to reporting, as well as of quality oversight of CRO and vendors, authoring study protocols, developing program strategy, country feasibility, contingency planning and associated timelines. She also has a record of working across numerous therapeutic areas, including pain, allergy and respiratory, immunology and vaccine development.

Image
Shirish Joshi
BSc MSc
Director Clinical Operations
Biography

Shirish is a clinical operations professional with more than 28 years’ experience working across Advanced Therapy Medicinal Products, diabetes, inflammatory, neurodegenerative, obstetric, oncology, osteoporosis, paediatric, rare diseases, and other medical condition drug development portfolios. He brings a significant track record of setting up and conducting national, EU, and global phase I, II, IIa, III, IIIb, and IV trials; designing study protocols; line-managing CRAs and CTAs; and managing drug development programmes and study budgets.

Image
Jeremy O'Sullivan
BSc MICR
Manager Clinical Operations
Biography

Jeremy is a clinical research management professional with 20 years’ experience in the pharmaceutical industry, during which time he has built an impressive record in planning, setting up, coordinating, managing and overseeing every aspect of early phase clinical trials both nationally and globally. His experience extends to multiple therapeutic areas in healthy volunteer and patient studies, including immunology, respiratory and endocrinology, neurology, neurotoxins and paediatric spasticity, and urology; and is skilled at maintaining trial recruitment and site progress in challenging circumstances – exhibited most recently during the Covid-19 lockdown of spring/summer 2020.

Image
Seema Parikh
BSc MBBS FPM MRQA
Senior Drug Development Clinician
Biography

Seema is a pharmaceutical physician with extensive experience of product and clinical development, regulatory and medical affairs, pharmacovigilance, and business development across the pharmaceutical, clinical and academic sectors. She brings a track record with biologicals and synthetics across multiple therapeutic areas, including oncology, inflammation, dermatology, neurology, and musculoskeletal disease, and considerable experience with orphan products and use of accelerated approval pathways.

Image
Graham Scott
BSc PhD MRPharmS
Clinical Pharmacologist
Biography

Graham is a pharmacist and clinical pharmacologist with more than 30 years’ experience across the pharmaceutical industry and extensive knowledge of translational science. He has a significant track record of completing programs from candidate selection through First in Human and Proof of Mechanism/Proof of Concept to submission and approval, and brings a drug development experience portfolio that includes approved therapies and medications such as Rozerem, Vepidia, Vipdomet (FDC), Incresyn (FDC), Edarbi and Adcetric (ADC). Graham’s expertise extends to combined protocol designs, exposure directed dose selection, faster FIH submissions, Translational Research Partnerships, F-NMR ADME, light label ADME, and simultaneous absolute bioavailability approaches.

Image
Harjit Singh
BSc
Director Clinical Operations
Biography

Harjit is a clinical operations and project management professional with more than 18 years’ experience of working across diabetes, immunology, immuno-oncology, hypertension, neurodegenerative, oncology, rare disease, rare cystic fibrosis drugs, renal, and other therapeutic portfolios. He brings a significant track record of designing, managing and leading international and multicentre studies through phases I, II, III, IIIb, and IV; setting up clinical development teams; developing study protocols; and devising clinical development plans and study timelines.

Image
Arash Yavari
MBBS DPhil MRCP
Senior Drug Development Clinician
Biography

Arash is a clinician scientist and drug development professional with over 20 years’ clinical and research experience. He has extensive experience across general internal medicine specialities, is on the GMC specialist register for cardiology and holds a research appointment in Experimental Therapeutics at the Radcliffe Department of Medicine, University of Oxford. He has broad experience in drug development including target discovery, early phase clinical trial design, immunology, oncology, Mendelian/rare disorders, oligonucleotide therapeutics, cardiovascular disease, drug repositioning and novel platform/precision medicine approaches, encompassing trial design, project management and delivery.

Operations

Image
Bryony Harraway
Head of Finance and Operations
Biography

Bryony is an operations and company creation executive with more than 10 years’ experience of working in the R&D and biotechnology industries. She brings a track record in company management and experience that extends to all aspects of the business, including financial planning, statutory compliance, forecasting, company fundraising, investor management, and post-investment scaling of early stage biotechs. With several successful consultancies to her name, Bryony is also familiar with the needs of SMEs and of pre/seed start-ups in particular.

Image
Caroline McHugh
BSc
Events Manager
Biography

Caroline is a project and event management professional with more than 20 years’ experience across the healthcare, hospitality, information technology industries. She is an expert negotiator and brings substantial experience of working internationally in the production of small- and large-scale events to budget and with finesse, incorporating summits, incentive programmes, sales kick-off meetings, advisory boards, and leadership events.

Image
Armin Yavari
BA MA MLitt FRSA
Finance and Operations Analyst
Biography

Armin is a non-profit management and operations professional with experience across the higher education and biotech landscapes. He co-organises the largest area studies early career conference series in Europe and heads an independent program devoted to connecting, challenging, educating and inspiring the next generation of academic talent in the humanities and social sciences.

Questions?
Get in touch.

Services
Emma Tinsley
[email protected]

Careers
Bryony Harraway
[email protected]

© 2021 Weatherden Limited • All Rights Reserved